Primordial Genetics is a biotechnology company focused on improving the performance of bio-production systems, and enabling the development and improvement of microbes and enzymes used in pharmaceutical & industrial manufacturing and in agriculture. We develop and use whole-genome synthetic biology genetic tools to create efficient production organisms and industrial enzymes. Function Generator, the company’s flagship technology, enables rapid and flexible development of novel biological products and traits required for microbial production of amino acids, proteins, chemicals and other useful compounds. The technology is highly effective at overcoming ‘genetic black box’-type biological productivity or enzymatic activity bottlenecks that have resisted other attempts at improvement.


Primordial Genetics Inc. has developed Function Generator™, a novel combinatorial gain-of-function genetic technology designed to enhance productivities of microbes used for the production of proteins (therapeutic proteins, industrial enzymes) and chemicals / fuels / pharmaceuticals. Function Generator™ has been validated in baker’s yeast (Saccharomyces cerevisiae) and the laboratory bacterium Escherichia coli.


Microbes are widely used for bio-production. Genetic optimization – creating improved strains of microbes for maximum efficiency and productivity – is currently difficult, slow and expensive. Function Generator™ is capable of dramatic improvement of productivities, tolerances and growth characteristics in production organisms to achieve economic and sustainable biological production systems.


The company is seeking partnerships to improve industrial production organisms and systems in a variety of industries: pharmaceuticals, feed & food ingredients, renewable chemicals & fuels, food processing and agricultural biotechnology. Our internal R&D is focused on producing superior bacterial strains for amino acid and protein production. In particular, we are creating bacterial strains for producing L-Methionine, an essential and high-value amino acid used in animal feed.


Primordial Genetics is working to become a leading provider of genetic solutions for microbial improvement. Our ultimate goal is to be able to shape the genetics and characteristics of useful organisms rapidly and flexibly – like clay in our hands. Primordial Genetics also has unique and powerful protein engineering capabilities that are being put to use together with our partners to develop next-generation enzymes for pharmaceutical and industrial applications.

Building Better Microbes with Function Generator

Cost Reduction

    Reduction in R&D cost
    Lower commercial CAPEX and OPEX
    Accelerated production runs translating into higher production capacity
    Design flexibility due to use of inexpensive production hosts

High Efficacy

    Improved protein solubility & expression
    Increased product titers and yields
    Enhanced growth and stress/product tolerances
    Improved enzymes and trait genes

Time Savings

    Accelerated strain development
    Transferable traits encoded by single genes
    Higher phenotypic gain per improvement cycle
    50-75% reduction in commercial strain development time

Novel Products

    Therapeutic proteins
    Industrial enzymes
    Trait genes
    New IP and FTO

Function Generator™ has been validated in baker’s yeast (Saccharomyces cerevisiae) and the laboratory bacterium Escherichia coli. The company is seeking partnerships to apply this promising genetic technology to improving industrial production organisms and systems, and developing improved industrial and pharmaceutical enzymes. Our internal R&D is aimed at producing superior E. coli strains for amino acid and protein production, with a specific focus on biological production of L-methionine.

Traditional methods vs Primordial Genetics methods